Oral contraceptive use was not associated with depression in a recent double-blind, randomized, placebo-controlled trial. Out of 162 women randomized to using 150 micrograms levonorgestrel and 30 micrograms ethinyl estradiol and 167 randomized to placebo pills, 7% of women in each group were moderately to severely depressed after 3 months. This study, with a strong study design is a powerful response contradicting findings an earlier and weaker study that had claimed a depression link (see the December LateBreaker “Make Me Cry: Depression Link (Again).”
“This is a big moment for women’s health,” says researcher Dr. David Goldman, of the NIH’s National Institute on Alcohol Abuse and Alcoholism. Goldman and his colleagues discovered a gene complex in women with premenstrual dysphoric disorder (PMDD). In their research, this gene complex was associated with a genetically disordered cellular response after being exposed to estrogen and progestin. Goldman hopes that what they learn about the genetic response could one day lead to improved, targeted treatment for PMDD and related disorders.
In a newly updated comprehensive summary, the PDQ Cancer Cancer Genetics editorial board estimates that in 2017, 250,000 women will be diagnosed with breast cancer and about 40,000 women will die of their cancer. The incidence of breast cancer, particularly estrogen-receptor positive tumors, continues to decline, with a marked decline beginning in 2003, about the time hormone therapy for menopausal symptoms was restricted to fewer years of use for symptom relief and many women discontinued use altogether due to the results from the randomized controlled trial conducted by the Women’s Health Initiative. Still, some women face greater risk of developing breast cancer than do others. The question of risk is especially compelling for the 5% to 10% of women whose mother or sister who has had breast cancer.
The “Contraceptive Technology” conferences will help you synthesize the data and translate the evidence into clinical “pearls” you can put directly into practice. With an array of Preconferences delving into selected specialty areas of interest, plenary sessions focusing on the “hottest” topics, a thought-provoking luncheon presentation, and 30 dynamic, interactive Concurrent Sessions, including hands-on workshops…this conference is certain to improve your clinical practice and expand your network of colleagues. Read more